{
  "id": "medical/iv-pump-rate-calculation-error-neonatal",
  "signature": "AI calculates IV pump rate for dopamine infusion using adult weight-based dosing for a neonate, leading to potential overdose",
  "signature_zh": "AI使用成人基于体重的剂量计算新生儿多巴胺输注的IV泵速率，可能导致过量用药",
  "regex": "dopamine.*(infusion|dose|rate).*(neonatal|newborn|infant).*(adult|overdose|miscalc)",
  "domain": "medical",
  "category": "data_error",
  "subcategory": null,
  "root_cause": "Dopamine infusion rates for neonates require weight-based dosing in mcg/kg/min, but AI incorrectly applies adult fixed-rate calculations (e.g., 5-20 mcg/kg/min for adults vs. 2-10 mcg/kg/min for neonates), leading to a twofold or greater overdose risk.",
  "root_cause_type": "generic",
  "root_cause_zh": "新生儿多巴胺输注速率需要基于体重的微克/公斤/分钟剂量计算，但AI错误地应用成人固定速率计算（例如成人5-20微克/公斤/分钟 vs 新生儿2-10微克/公斤/分钟），导致两倍或更高的过量风险。",
  "versions": [
    {
      "version": "dopamine IV 40 mg/mL concentrate",
      "introduced": null,
      "deprecated": null,
      "removed": null,
      "behavior_change": null,
      "status": "active"
    },
    {
      "version": "neonatal infusion pump (Alaris 8015)",
      "introduced": null,
      "deprecated": null,
      "removed": null,
      "behavior_change": null,
      "status": "active"
    },
    {
      "version": "weight-based dosing protocol v2.3",
      "introduced": null,
      "deprecated": null,
      "removed": null,
      "behavior_change": null,
      "status": "active"
    }
  ],
  "os_specific": {},
  "dead_ends": [
    {
      "action": "",
      "why_fails": "Adult nomograms assume higher baseline blood pressure and different receptor sensitivity; applying them to neonates can cause hypertension, tachycardia, and extravasation injury.",
      "fail_rate": 0.85,
      "condition": "",
      "sources": []
    },
    {
      "action": "",
      "why_fails": "Neonates lose weight after birth and then regain; using birth weight leads to underdosing or overdosing depending on day of life.",
      "fail_rate": 0.65,
      "condition": "",
      "sources": []
    },
    {
      "action": "",
      "why_fails": "Fixed rate without concentration adjustment ignores the required mcg/kg/min target, leading to therapeutic failure or toxicity.",
      "fail_rate": 0.75,
      "condition": "",
      "sources": []
    }
  ],
  "workarounds": [
    {
      "action": "Use the neonatal dopamine infusion calculator: dose (mcg/kg/min) × weight (kg) × 60 (min/hr) ÷ concentration (mcg/mL) = rate (mL/hr). For a 3 kg neonate requiring 5 mcg/kg/min from a 1600 mcg/mL solution (40 mg in 25 mL D5W), rate = 5 × 3 × 60 / 1600 = 0.56 mL/hr.",
      "success_rate": 0.92,
      "how": "Use the neonatal dopamine infusion calculator: dose (mcg/kg/min) × weight (kg) × 60 (min/hr) ÷ concentration (mcg/mL) = rate (mL/hr). For a 3 kg neonate requiring 5 mcg/kg/min from a 1600 mcg/mL solution (40 mg in 25 mL D5W), rate = 5 × 3 × 60 / 1600 = 0.56 mL/hr.",
      "condition": "",
      "sources": []
    },
    {
      "action": "Verify with a second calculator (e.g., PediTools or NICU dose calculator) before programming the pump.",
      "success_rate": 0.98,
      "how": "Verify with a second calculator (e.g., PediTools or NICU dose calculator) before programming the pump.",
      "condition": "",
      "sources": []
    },
    {
      "action": "Use a standardized neonatal dopamine infusion protocol with pre-calculated tables for common weights (1-5 kg) and desired doses.",
      "success_rate": 0.95,
      "how": "Use a standardized neonatal dopamine infusion protocol with pre-calculated tables for common weights (1-5 kg) and desired doses.",
      "condition": "",
      "sources": []
    }
  ],
  "workarounds_zh": [
    "Use the neonatal dopamine infusion calculator: dose (mcg/kg/min) × weight (kg) × 60 (min/hr) ÷ concentration (mcg/mL) = rate (mL/hr). For a 3 kg neonate requiring 5 mcg/kg/min from a 1600 mcg/mL solution (40 mg in 25 mL D5W), rate = 5 × 3 × 60 / 1600 = 0.56 mL/hr.",
    "Verify with a second calculator (e.g., PediTools or NICU dose calculator) before programming the pump.",
    "Use a standardized neonatal dopamine infusion protocol with pre-calculated tables for common weights (1-5 kg) and desired doses."
  ],
  "transition_graph": {
    "leads_to": [],
    "preceded_by": [],
    "frequently_confused_with": []
  },
  "official_doc_url": "https://www.uptodate.com/contents/dopamine-drug-information",
  "official_doc_section": null,
  "error_code": "DOPAMINE_NEONATAL_DOSE_ERR",
  "verification_tier": "ai_generated",
  "confidence": 0.88,
  "fix_success_rate": 0.85,
  "resolvable": "true",
  "first_seen": "2024-11-15",
  "last_confirmed": "2024-06-01",
  "last_updated": "2024-06-01",
  "evidence_count": 1,
  "tags": [],
  "locale": "en",
  "aliases": []
}