ERR_DRUG_INTERACTION_MAOI medical data_error ai_generated true

AI recommends a common cold medication containing pseudoephedrine to a patient on a monoamine oxidase inhibitor (MAOI) like phenelzine

ID: medical/pseudoephedrine-maoi-interaction

Also available as: JSON · Markdown · 中文
90%Fix Rate
90%Confidence
1Evidence
2024-01-20First Seen

Version Compatibility

VersionStatusIntroducedDeprecatedNotes
Lexicomp Drug Interactions v5.2 active — — —
UpToDate v2024.1 active — — —
FDA Orange Book 2024 active — — —

Root Cause

Pseudoephedrine is a sympathomimetic amine that releases norepinephrine; MAOIs inhibit norepinephrine breakdown, causing synergistic hypertensive crisis with potential intracranial hemorrhage.

generic

中文

伪麻黄碱是释放去甲肾上腺素的拟交感胺；MAOIs 抑制去甲肾上腺素分解，协同作用导致高血压危象，可能引发颅内出血。

Official Documentation

https://www.fda.gov/drugs/drug-interactions-labeling

Workarounds

  1. 95% success Use saline nasal spray (0.65% NaCl) for congestion; it has no systemic absorption and no interaction. 
    Use saline nasal spray (0.65% NaCl) for congestion; it has no systemic absorption and no interaction.
  2. 85% success Consider intranasal corticosteroids (e.g., fluticasone 50 mcg/spray) as safe alternative. 
    Consider intranasal corticosteroids (e.g., fluticasone 50 mcg/spray) as safe alternative.

中文步骤

  1. Use saline nasal spray (0.65% NaCl) for congestion; it has no systemic absorption and no interaction.
  2. Consider intranasal corticosteroids (e.g., fluticasone 50 mcg/spray) as safe alternative.

Dead Ends

Common approaches that don't work:

  1. 30% fail

    Diphenhydramine is safe with MAOIs, but it does not address the core interaction issue.

  2. 90% fail

    No safe dose threshold exists for pseudoephedrine with MAOIs; any amount can cause severe hypertension.