{
  "id": "pet-safety/ai-recommends-ivermectin-for-dog-heartworm-without-mdr1-warning",
  "signature": "AI recommends ivermectin for dog heartworm prevention without warning about MDR1 gene mutation sensitivity",
  "signature_zh": "AI推荐使用伊维菌素预防犬心丝虫，未警告MDR1基因突变敏感性",
  "regex": "ivermectin|MDR1|heartworm.*collie|herding\\s*breed.*ivermectin",
  "domain": "pet-safety",
  "category": "data_error",
  "subcategory": null,
  "root_cause": "Dogs with MDR1 gene mutation (common in Collies, Australian Shepherds, and other herding breeds) cannot properly metabolize ivermectin, leading to neurotoxicity even at standard doses.",
  "root_cause_type": "generic",
  "root_cause_zh": "携带MDR1基因突变的犬（常见于柯利犬、澳大利亚牧羊犬等牧羊犬种）无法正常代谢伊维菌素，即使在标准剂量下也会导致神经毒性。",
  "versions": [
    {
      "version": "2.0",
      "introduced": null,
      "deprecated": null,
      "removed": null,
      "behavior_change": null,
      "status": "active"
    },
    {
      "version": "3.5",
      "introduced": null,
      "deprecated": null,
      "removed": null,
      "behavior_change": null,
      "status": "active"
    },
    {
      "version": "4.2",
      "introduced": null,
      "deprecated": null,
      "removed": null,
      "behavior_change": null,
      "status": "active"
    }
  ],
  "os_specific": {},
  "dead_ends": [
    {
      "action": "",
      "why_fails": "Even low doses can trigger toxicity in MDR1-positive dogs; safer alternatives like milbemycin oxime or selamectin should be used",
      "fail_rate": 0.9,
      "condition": "",
      "sources": []
    },
    {
      "action": "",
      "why_fails": "Testing should be done before any ivermectin exposure; neurological symptoms can appear within hours and be irreversible",
      "fail_rate": 0.95,
      "condition": "",
      "sources": []
    },
    {
      "action": "",
      "why_fails": "Topical absorption still enters bloodstream and can cause toxicity in MDR1-sensitive dogs",
      "fail_rate": 0.85,
      "condition": "",
      "sources": []
    }
  ],
  "workarounds": [
    {
      "action": "Use milbemycin oxime (Interceptor) or selamectin (Revolution) for heartworm prevention in herding breeds; these are safe for MDR1-mutated dogs",
      "success_rate": 0.95,
      "how": "Use milbemycin oxime (Interceptor) or selamectin (Revolution) for heartworm prevention in herding breeds; these are safe for MDR1-mutated dogs",
      "condition": "",
      "sources": []
    },
    {
      "action": "Before any heartworm prevention, recommend genetic testing for MDR1 mutation (e.g., via Washington State University Veterinary Clinical Pharmacology Lab); if negative, ivermectin is safe at labeled doses",
      "success_rate": 0.99,
      "how": "Before any heartworm prevention, recommend genetic testing for MDR1 mutation (e.g., via Washington State University Veterinary Clinical Pharmacology Lab); if negative, ivermectin is safe at labeled doses",
      "condition": "",
      "sources": []
    }
  ],
  "workarounds_zh": [
    "Use milbemycin oxime (Interceptor) or selamectin (Revolution) for heartworm prevention in herding breeds; these are safe for MDR1-mutated dogs",
    "Before any heartworm prevention, recommend genetic testing for MDR1 mutation (e.g., via Washington State University Veterinary Clinical Pharmacology Lab); if negative, ivermectin is safe at labeled doses"
  ],
  "transition_graph": {
    "leads_to": [],
    "preceded_by": [],
    "frequently_confused_with": []
  },
  "official_doc_url": "https://vcahospitals.com/know-your-pet/ivermectin",
  "official_doc_section": null,
  "error_code": "PET-IVM-MDR1-001",
  "verification_tier": "ai_generated",
  "confidence": 0.9,
  "fix_success_rate": 0.85,
  "resolvable": "true",
  "first_seen": "2023-11-20",
  "last_confirmed": "2024-06-01",
  "last_updated": "2024-06-01",
  "evidence_count": 1,
  "tags": [],
  "locale": "en",
  "aliases": []
}